Dr. Tanju YILDÖN & Tıp Bilim Eğitimi

4. kuşak Flurokinolonlar DNA TopoizomerazII&IV inhibisyonu yaparlar. 4. kuşak kinolonlar: Moksifl oksasin, gemifl oksasin, gatifl oksasin gibi ilaçlardır

Topoisomerase

Subfamily Type

Topoisomerase I

(E. coli)

Type IA

Topoisomerase III

(E. coli)

Topoisomerase IIIα

(H. sapiens)

Topoisomerase IIIβ

(H. sapiens)

Reverse DNA Gyrase

(E. coli)

Reverse DNA Gyrase

(Archaea)

Topoisomerase I

(H. sapiens)

Type IB

Topoisomerase V

(Archaea)

Type IC

Topoisomerase II / DNA Gyrase

(E. coli)

Type IIA

Topoisomerase IV

(E. coli)

Topoisomerase IIα

(H. sapiens)

Topoisomerase IIβ

(H. sapiens)

Topoisomerase VI

(Archaea)

Type IIB