Dr. Tanju YILDÖN & Tıp Bilim Eğitimi

Distrofik kalsifikasyon

Dystrophic vs metastatic calcification | Metastatic, Subcutaneous tissue,  Pagets disease

Pathologic calcification

Dystrophic Calcification: Dead Tissue
• Caseous necrosis in tuberculosis is the most common site
• Liquefaction necrosis i...

Calcification in dead tissue

1-Caseous necrosis in T.B. is most common site of dystrophic calcification.

2-Liquefactive necrosis in chronic abscesses may get calcified.

3-Fat necrosis following acute pancreatitis or traumatic fat necrosis in breasts results in deposition of calcium soaps.

4-Infarcts may undergo D.C.

5-Thrombi, especially in veins, may produce phlebolithis.

6-Haematomas in the vicinity of bones may undergo D.C.

7-Dead parasites like schistosoma eggs may calcify.

8-Congenital toxoplasmosis, CMV or rubella may be seen on X-ray as calcifications in the brain.

Dystrophic Calcification: Dead Tissue
• Thrombi, especially in the veins, may produce
• Haematomas in the vic...

Dystrophic calcification: Degenerated
• Dense old scars may undergo hyaline degeneration
and subsequent calcificat...
Calcification in degenerated tissue

1-Dense scars may undergo hyaline degeneration and calcification.

2-Atheroma in aorta and coronaries frequently undergo calcification.3-Cysts can show calcification.

4-Calcinosis cutis is condition in which there are irregular nodular deposits of calcium salts in skin and subcutaneous tissue.

5-Senile degenerative changes may be accompanied by calcification.

6-The inherited disorder pseudoxanthoma elasticum may lead to angioid streaks with calcification of Bruch's membrane, the elastic tissue below the retinal ring.

Dystrophic calcification: Degenerated
• Psammoma bodies or calcospherites: characteristic
spherules of calcificati...

Dystrophic calcification
Fibrosis and dystrophicFibrosis and dystrophic
calcifications of the
pancreatic parenchyma.

Dystrophic calcification
Mitral Stenosis:
Gross natural
color openedcolor opened
valve with
commissure fusion

Dystrophic soft tissue calcification is a type of soft-tissue calcification, which occurs in damaged or necrotic tissue, while the serum level of calcium and phosphorus are normal. It may progress to ossification, in which case a cortical and trabecular bone pattern is visible.

Differential diagnosis 


venous insufficiency
Mönckeberg arteriosclerosis 

Dystrophic calcification
Degenerated tunica media of muscular
artery of uterine myometrium in
Mönckeberg’s arteriosclerosi...


granulomatous infection
parasitic infestation
Armillifer armillatus

Dystrophic calcification: Pathogenesis
• Denatured proteins in necrotic or degenerated tissue
bind phosphate ions, which r...


primary bone-forming tumors: osteosarcoma
other sarcomas: specially synovial sarcoma
tumor necrosis


vitamin D
milk-alkali syndrome


scleroderma and CREST syndrome
systemic lupus erythematosus 


heterotopic ossification
injection granuloma