Dr. Tanju YILDÖN & Tıp Bilim Eğitimi

Topoizomeraz II üzerinden katalitik inhibisonu yapan antineoplastikler; Dexrazoxane, Novobiocin, Merbarone, Anthrycycline ve Aclarubicin


I-Topoisomerase I İnhibitors

Anticancer drugs

1-Camptothecins; topotecan (TPT), irinotecan, belotecan, silatecan

2-Non-camptothecins, indenoisoquinoline, phenanthridines, 

II-Topoisomerase II İnhibitors

1-Antibiotics

a-Aminocoumarins novobiocin, coumermycin, actinomycin A, actinomycin B

b-Quinolones

First generation: nalidixic acid

Second generation: cinoxacin, norfloxacin, ciprofloxacin

Third generation: levofloxacin, sparfloxacin

Fourth generation: moxifloxacin

2-Anticancer therapeutics

a-Intercalating poisons

Doxorubicin

Daunorubicin (doxorubicin precursor)

Epirubicin (a doxorubicin stereoisomer)

Idarubicin (a daunorubicin derivative)

b-Non-intercalating poisons

Etoposide

Teniposide

c-Mutations; anthracyclines family

d-Catalytic inhibitors

Dexrazoxane

Novobiocin

Merbarone

Anthrycycline

Aclarubicin